Method of treatment
AssigneeQBiotics Limited
InventorsPeter Gordon PARSONS, Peter Frederick SCHMIDT, Charles Stewart LOWDEN, Justine Emma CAMPBELL, Victoria GORDON
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Abstract
The present invention relates to methods of treating mast cell tumors and soft tissue sarcomas using 6,7-epoxy-4,5,9,12,13,20-hexahydroxy-1-tigliaen-3-one derivatives in combination with at least one other pharmaceutically active agent. In particular embodiments, the tigliaen-3-one derivatives are 12, 13-acyl or ether derivatives and the derivative compound is delivered in a localised manner to the tumor or sarcoma. In particular embodiments, the at least one other pharmaceutically active agent is selected from an antihistamine, an anti-inflammatory agent and mixtures thereof.
Claims24
A method of treating a mast cell tumor or a soft tissue sarcoma in a subject comprising administering to the subject a compound of formula (I):
- wherein R1 and R2 are independently selected from —C1-20alkyl, —C2-20alkenyl, —C2-20alkynyl, —C(O)C1-20alkyl, —C(O)C2-20alkenyl and —C(O)C2-20alkynyl;
- wherein each alkyl, alkenyl and alkynyl may be optionally substituted with one or more groups selected from —OH, —SH, —OC1-4alkyl, —SC1-4alkyl, -halo, —CN, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2, —OCH2F, —SCF3, —SCHF2, —SCH2F, —CO2H, —CO2C1-4alkyl, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2 and —NO2;
- or a pharmaceutically acceptable salt thereof;
- in combination with at least one other pharmaceutically active agent.
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A method of treating a mast cell tumour in a subject comprising administering a compound of formula (I) in combination with at least one anti-inflammatory compound and at least one antihistamine;
- wherein the compound of formula (I) is
- wherein R1 and R2 are independently selected from —C1-20 alkyl, —C2-20alkenyl, —C2-20alkynyl, —C(O)C1-20alkyl, —C(O)C2-20alkenyl and —C(O)C2-20alkynyl:
- wherein each alkyl, alkenyl and alkynyl may be optionally substituted with one or more groups selected from —OH, —SH, —OC1-4alkyl, —SC1-4alkyl, -halo, —CN, —CF3, —CF2, —CH2F, —OCF3, —OCHF2, —OCH2F, —SCF3—SCHF2, —SCH2F, —CO2H, —CO2C1-4alkyl, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2 and —NO2;
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.