Compositions and methods for the treatment of pulmonary arterial hypertension
AssigneeThe Regents of the University of Michigan
InventorsDavid Pinsky, Scott H. Visovatti
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Abstract
Provided herein are compositions and methods for the treatment of pulmonary arterial hypertension. In particular, compositions and methods are provided that address purinergic dysregulation, the causes thereof, and/or the effect of downstream targets.
Claims28
A method of treating pulmonary arterial hypertension (PAH) in a subject, comprising administering to the subject an agent that degrades extraellular ATP.
A method of treating pulmonary arterial hypertension (PAH) in a subject, comprising administering to the subject an adenosine analogue.
A method of treating pulmonary arterial hypertension (PAH) in a subject, comprising administering to the subject purinergic receptor antagonist.
A method of treating pulmonary arterial hypertension (PAH) in a subject, comprising administering to the subject an inhibitor of ATP synthesis and/or ATP-release from cells into the extracellular environment.
Dependencies are inferred from the claim text.