Agents useful for treating obesity, diabetes and related disorders
AssigneeThe Regents of the University of California
InventorsGino Cortopassi, Alexey A. Tomilov
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Abstract
This invention provides methods of treatment diabetes and related conditions using idebenone and analogs thereof compounds 10, 11, 12 and DF-1176-178.
Claims15
A method of treating or effecting prophylaxis of impaired insulin sensitivity, glucose tolerance or obesity, comprising administering to a subject having the impaired insulin sensitivity, glucose tolerance or obesity an effective regime of compound 10, compound 11, compound 12, compound DF1176-78 or idebenone, or a pharmaceutically acceptable salt thereof, thereby treating or effecting prophylaxis of the impaired insulin sensitivity, glucose tolerance or obesity.
A method of treating or effecting prophylaxis of metabolic syndrome, comprising administering to a subject having or at risk of metabolic syndrome an effective regime of compound 10, compound 11, compound 12, compound DF1176-78 or idebenone or a pharmaceutically acceptable salt thereof, thereby treating or effecting prophylaxis of the syndrome.
A method of inhibiting aging, comprising administering to a subject an effective regime of compound 10, compound 11, compound 12, compound DF-1176-178, or idebenone or a pharmaceutically acceptable salt thereof, thereby inhibiting aging.
A method of inhibiting development of type 2 diabetes or metabolic syndrome in a subject receiving corticosteroid treatment, comprising administering an effective regime of idebenome, compound 10, compound 11, compound 12 or compound DF1176-78, or a pharmaceutically acceptable salt thereof, and thereby inhibiting development of type 2 diabetes or metabolic syndrome.
A method of treating a subject having non-alcoholic steatohepatitis comprising administering to the subject an effective regime of idebenome, compound 10, compound 11, compound 12 or compound DF1176-78, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.