Transdermal Packaging Membranes
AssigneeAgile Therapeutics, Inc.
InventorsAgis KYDONIEUS, C. Gregory ARNOLD, Robert G. CONWAY, Thomas M. ROSSI
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Abstract
Article side polymers useful in the packaging of transdermal patches are disclosed. These films do not absorb skin permeation enhancers that are contained in transdermal patches including keto acids such as levulinic acid or sulfoxides such as an alkyl sulfoxide, e.g., dimethyl sulfoxide. Using such polymeric film, multilayer pouch constructions can be manufactured which include other polymeric layers, such as aluminum foil for moisture and oxygen barrier properties, polyester for tear resistance and paper layers for optimal printing and design.
Claims20
A pouch for storing a transdermal delivery patch comprising an active pharmaceutical ingredient and
- (i) at least one skin penetration enhancer that is a keto acid and at least one additional enhancer that is a long chain monoglyceride or a C8-C16 ester of a short chain carboxylic acid, or
- (ii) at least one skin penetration enhancer that is a sulfoxide,
- wherein the pouch comprises a multilayered packaging film comprising an article side polymer layer selected from a fluoropolymer, polypropylene, polyethylene terephthalate, a low density polyethylene (LDPE), a cyclic olefin copolymer, or polyacrylonitrile/methyl acrylate-acrylonitrile/butadiene graft copolymer.
A pouch for storing a transdermal delivery patch, the patch comprising a backing layer affixed to an adhesive polymer matrix, wherein the adhesive polymer matrix comprises:
- a. an active pharmaceutical ingredient;
- b. an adhesive polymer;
- and
- c. (i) a first penetration enhancer selected from the group consisting of a keto acid and a pharmaceutically acceptable salt thereof and a second penetration enhancer selected from the group consisting of long chain monoglycerides and C8-C16 esters of short chain carboxylic acid or
- (ii) a first penetration enhancer selected from the group consisting of alkyl sulfoxides and a second penetration enhancer selected from the group consisting of C8-C16 esters of a short chain carboxylic acid, lower alkyl esters of a short chain carboxylic acid, or both;
- wherein the pouch comprises a multilayered packaging film comprising an article side polymer layer selected from a fluoropolymer, polypropylene, polyethylene terephthalate, a low density polyethylene (LDPE), a cyclic olefin copolymer, or polyacrylonitrile/methyl acrylate-acrylonitrile/butadiene graft copolymer.
Dependencies are inferred from the claim text.