Loading patent…
AssigneeIndustry-University Cooperation Foundation Hanyang University Erica Campus
InventorsHyemin SEO, Kyounghee SHIN, Jinyong LEE, Jin Woong KIM
Estimating the term…
Multilayer thin emulsion films are disclosed. Also disclosed are methods for preparing the multilayer thin emulsion films. According to the methods, an amphiphilic block polymer is used as a surfactant to form a polymer thin film at the oil/water interface, ionic lecithin is used as an auxiliary surfactant to prepare physically stable ionic oil-in-water nanoemulsions, and a layer-by-layer assembly technique is used to alternately laminate polymer thin films and nanoemulsion layers. The multilayer thin emulsion films enable slow release of active substances in specific temperature ranges and are structurally biocompatible while possessing improved capture efficiency and physically stable membrane structures. Spinodal decomposition of the multilayer thin emulsion films is induced by heating, allowing release of oils and active substances loaded into the nanoemulsions. Therefore, the multilayer thin emulsion films are expected to be useful as smart drug release materials in a variety of applications, including cosmetics, pharmaceuticals, and biotherapy.
A multilayer thin emulsion film comprising a substrate and 1 to 100 layers of composite thin films laminated on the substrate to release an active substance in a specific temperature range wherein each of the composite thin films consists of a cross-linkable positively charged polymer layer coated on the substrate surface and a nanoemulsion layer comprising a plurality of nanoemulsions arrayed on the polymer layer and wherein each of the nanoemulsions is a spherical particle consisting of (a) a core comprising the active substance and an oil and a shell comprising (b) an amphiphilic polymer consisting of a biodegradable hydrophobic polymer composed of poly(ester) and a hydrophilic polymer composed of poly(ethylene oxide) and (c) lecithin and continuously or discontinuously surrounding the core.
A multilayer thin emulsion film comprising a substrate, 1 to 100 layers of first composite thin films, and 1 to 100 layers of second composite thin films wherein the first composite thin films and the second composite thin films are laminated alternately with each other on the substrate, wherein each of the first composite thin films releases an active substance in a specific temperature range and consists of a cross-linkable cationic polymer layer coated on the substrate surface and a nanoemulsion layer comprising a plurality of nanoemulsions arrayed on the polymer layer, wherein each of the second composite thin films is disposed on the first composite thin film and consists of a cross-linkable cationic polymer layer coated on the surface of the first composite thin film and a nanofiber layer formed on the polymer layer, and wherein each of the nanoemulsions is a spherical particle consisting of (a) a core comprising the active substance and an oil and a shell comprising (b) an amphiphilic polymer consisting of a hydrophobic polymer and a hydrophilic polymer and (c) lecithin and continuously or discontinuously surrounding the core.
A method for preparing a multilayer thin emulsion film, comprising:
Dependencies are inferred from the claim text.