Mesoporous silica nanoparticles with a lipid bilayer coating for cargo delivery
AssigneeThe Regents of the University of California
InventorsAndre E. Nel, Huan Meng, Xiangsheng Liu
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Abstract
A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
Claims20
A method of treating cancer, comprising administering to a subject in need thereof an effective amount of a nanoparticle drug carrier, wherein the nanoparticle drug carrier comprises:
- a) a silica nanoparticle having a surface and defining a plurality of pores;
- b) a lipid bilayer coating the surface;
- and
- c) a drug disposed within the plurality of pores, wherein the nanoparticle drug carrier has a drug loading capacity of at least about 40% w/w.
Dependencies are inferred from the claim text.