Liposomal composition containing mild acidic active agent
AssigneesTaiwan Liposome Co., Ltd., Tlc Biopharmaceuticals, Inc.
InventorsKe-Ming Huang, He-Ru Chen, Keelung Hong
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Abstract
Provided is a method for preparing a liposomal composition. The method comprises the step of contacting a liposome solution with a mild acidic agent for a limited time. The liposome solution comprises a weak acid salt encapsulated within an aqueous interior space separated from the aqueous medium by a membrane comprised of a lipid mixture containing one or more lipids and a hydrophilic polymer conjugated lipid at a molar percentage of less than 3% based on the total amount of the lipid mixture. The time for encapsulating the agent to a desired amount at a predetermined ratio to lipids is dramatically reduced even under a condition without elevating the temperature to above ambient environment.
Claims23
1-5. (canceled)
A delivery vehicle, said delivery vehicle comprising a liposome in an aqueous medium, wherein the liposome comprises a combination of a weak acid salt and a polyprotic acid encapsulated within the liposome.
9-33. (canceled)
39-41. (canceled)
The delivery vehicle according to claim 1, wherein the weak acid salt is sodium acetate, potassium acetate or calcium acetate.
A liposomal composition, comprising
- a delivery vehicle, said delivery vehicle comprising a liposome in an aqueous medium, wherein the liposome comprises a combination of a weak acid salt and an organic tribasic acid encapsulated within the liposome, wherein the weak acid salt is sodium acetate, potassium acetate or calcium acetate;
- and
- an arachidonic acid metabolite.
Dependencies are inferred from the claim text.