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AssigneesJiangnan University, Max Planck Institute of Colloids and Interfaces
InventorsJian YIN, Jing HU, Peter Seeberger, Zhou YE
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The present disclosure discloses an integrated nano system for liver-targeting co-delivery of genes/drugs and a preparation method, belonging to the field of biomedicines. In the disclosure, a plurality of functions are integrated in a carrier having good biocompatibility and safety, a nucleic acid/drug-loading copolymer portion having a pH-stimulating response function is formed by poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) grafted with poly(3-azido-2-hydroxypropylmethacrylate) (PGMA-N3), and a fluorescence-based imaging component Rhodamine B (RhB) and galactose are used as targeting ligands. The drug delivery system provided by the present disclosure is safe, is capable of taking a synergistic effect of gene/drug therapy, and is expected to play a great role in clinical application.
A liver-targeting pH-sensitive tracing copolymer nano micelle system, comprising a copolymer formed by monomer N,N-dimethylaminoethyl methacrylate DMAEMA having pH sensitivity and hydrophobic monomer 3-azido-2-hydroxypropyl methacrylate PGMA-N3, wherein one end of the copolymer is modified with [Rhodamine B] a fluorescent molecule having a fluorescence tracing function, and the other end is modified with a galactose residue having a liver targeting function.
Dependencies are inferred from the claim text.