Improvements in cancer treatment
AssigneeNoxopharm Limited
InventorGraham KELLY
Life of this patent
Estimating the term…
Abstract
The invention relates to cancer therapy, especially to cytotoxic agents and chemo-sensitizing and radio-sensitising agents, particularly isoflavonoids, and to improving the bioavailability of same.
Claims26
A composition including:
- an oleaginous base for use in a device for rectal, vaginal or urethral application;
- a compound of general formula (I) contained or dissolved in the base
- wherein
- R1 is H, or RACO where RA is C1-10 alkyl or an amino acid;
- R2 is H, OH, or RB where RB is an amino acid or CORA where RA is as previously defined;
- A and B together with the atoms between them form a six membered ring selected from the group consisting of:
- wherein
- R4 is H, CORD where RD is H, OH, C1-10 alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10 alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined;
- R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different;
- X is O, N or S;
- Y is
- where R7 is H, or C1-10 alkyl;
- and
- “” represents either a single bond or a double bond.
A composition including:
- an oleaginous base for use in a device for rectal, vaginal or urethral application;
- a compound of general formula (II) contained or dissolved in the base
- wherein
- R1 is H, or RACO where RA is C1-10 alkyl or an amino acid;
- R2 is H, OH, or RB where RB is an amino acid or CORA where RA is as previously defined;
- A and B together with the atoms between them form the group:
- wherein
- R4 is H, CORD where RD is H, OH, C1-10 alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10 alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined;
- R5 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
- X is O, N or S;
- Y is
- where R7 is H, or C1-10 alkyl;
- and
- “” represents either a single bond or a double bond.
The composition of any one of the preceding claims wherein the oleaginous base is provided in an amount of about 1 to 99% w/w formulation.
The composition of any one of the preceding claims wherein the oleaginous base includes saturated fatty acids in an amount of 50 to 65% w/w base.
A suppository, pessary or like formed from a composition according to any one of the preceding claims.
A suppository, pessary or like formed from a composition according to any one of the preceding claims for use in preventing or treating cancer.
Dependencies are inferred from the claim text.