Method, system, and computer-accessible medium for assessment of glycosaminoglycan concentration in vivo by chemical exchange saturation transfer
AssigneeNew York University
InventorsWen LING, Minneapolis R. REGATTE, Gil NAVON, Alexej JERSCHOW
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Abstract
An exemplary methodology, procedure, system, method and computer-accessible medium can be provided to determine one or more particular frequencies of cross-relaxation between at least one molecule and at least one particular compound determine a chemical exchange based on magnetic resonance data using a further frequency which is different from the one or more particular frequencies, and derive particular information about the anatomical region of interest based on the chemical exchange.
Claims19
1-38. (canceled)
A non-transitory computer-accessible medium including instructions thereon for determining at least one of a concentration or a density of at least one molecule associated with at least one of glycosaminoglycan or proteoglycan contained within an anatomical region of interest, wherein, when a processing computer arrangement executes the instructions, the processing arrangement is configured to perform procedures comprising:
- receiving information including one or more nuclear Overhauser effect saturation transfer (“NOEST”) offsets in at least one region around −1.0 ppm or −2.6 ppm or −3.2 ppm relative to a water signal of the at least one compound;
- determining a nuclear Overhauser effect (NOE) based on one or more particular NOEST offsets using a NOEST pulse sequence applied to target the at least one molecule;
- generating a difference image of the anatomical region of interest between two images, relating to equal and opposite offsets, by subtracting dips of peaks at at least one of −1 ppm from the image of +1.0 ppm, or −2.6 ppm from the image of +2.6 ppm, or −3.2 ppm from the image of +3.2 ppm, based on the NOEST;
- and
- determining the concentration or the density of the at least one molecule based on the difference image.
A method for determining at least one of a concentration or a density of at least one molecule associated with at least one of glycosaminoglycan or proteoglycan contained within an anatomical region of interest comprising:
- receiving information including one or more nuclear Overhauser effect saturation transfer (“NOEST”) offsets in at least one region around −1.0 ppm or −2.6 ppm or −3.2 ppm relative to a water signal of the at least one compound;
- determining a nuclear Overhauser effect (NOE) based on one or more particular NOEST offsets using a NOEST pulse sequence applied to target the at least one molecule;
- generating a difference image of the anatomical region of interest between two images, relating to equal and opposite offsets, by subtracting dips of peaks at at least one of −1 ppm from the image of +1.0 ppm, or −2.6 ppm from the image of +2.6 ppm, or −3.2 ppm from the image of +3.2 ppm, based on the NOEST;
- and
- determining the concentration or the density of the at least one molecule based on the difference image.
Dependencies are inferred from the claim text.