Methods and systems for determining lumen volume and coronary blood flow

A system for determining a lumen volume of a target blood vessel, comprising:

• an interface configured to receive a temporal sequence of angiography images of the target blood vessel acquired after a contract agent is injected in the target blood vessel;
• and
• a processor configured to:
• identify a region of interest containing the target blood vessel in each angiography image in the temporal sequence of angiography images;
• integrate pixel values in each region of interest;
• and
• determine the lumen volume based on the integrated values of the regions of interest and a predetermined correlation between the integrated values and volumes of the contrast agent.

A non-transitory computer-readable storage medium having computer executable codes stored thereon, the computer executable codes, when executed by a processor, performing a method for determining a lumen volume of a target blood vessel, wherein method comprises:

• receiving a temporal sequence of angiography images of the target blood vessel acquired after a contract agent is injected in the target blood vessel;
• identifying a region of interest containing the target blood vessel in each angiography image in the temporal sequence of angiography images;
• integrating pixel values in each region of interest;
• and
• determining the lumen volume based on the integrated values of the regions of interest and a predetermined correlation between the integrated values and volumes of the contrast agent.