Ameliorative effects of a whole coffee fruit extract on age-related neurodegenerative disease
AssigneeLytone Enterprise, Inc.
InventorsWillian Tienhung CHANG, Weiting TSENG, Minghui CHEN
Life of this patent
Estimating the term…
Abstract
The invention provides a method of extracting whole coffee fruit, an extract obtained from the method, and method of ameliorating age-related neurodegenerative diseases using said extract. The whole coffee fruit extract may be extracted by water, methanol, ethanol, or acetone and may comprise chlorogenic acid (CA) and procyanidine. The expression levels of p-CREB, BDNF, p-eIF2α, BACE-1, Aβ, NLRP3, caspase-1, IL-1β and COX-2 which may relate to age-related neurodegenerative diseases can be modulated.
Claims14
A method of producing a whole coffee fruit extract, comprising the steps of:
- (a) providing freshly collected whole coffee fruit, optionally drying the whole coffee fruit so that the water content is 20% or less;
- (b) subjecting the dried whole coffee fruit of step (a) to extraction by a solvent selected from water, methanol, ethanol, and acetone;
- and
- (c) recovering the extract of step (b).
A method of ameliorating age-related neurodegenerative diseases, comprising administering to a subject in need thereof a therapeutically effective amount of a whole coffee fruit extract.
Dependencies are inferred from the claim text.