Nmr detection of coagulation time
AssigneeT2 Biosystems, Inc.
InventorsSonia TAKTAK, Brian M. MOZELESKI, Thomas J. LOWERY, JR.
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Abstract
The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.
Claims28
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A method for determining the coagulation state and/or coagulation time of a sample using a nuclear magnetic resonance (NMR) device, comprising:
- a) performing NMR measurements on a sample within a detection volume of an NMR detector of the NMR device to determine at least two values of T2 of the sample over time, the T2 being responsive to coagulation in the sample;
- and
- b) assessing the values determined in a) to obtain the coagulation state and/or coagulation time of the sample.
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A method for monitoring the coagulation of a sample from a test subject, the method comprising:
- (a) measuring a plurality of values of T2 of the sample over time, wherein the T2 is responsive to the coagulation state of the sample.
A method for diagnosing an abnormal clotting event in a sample of a test subject, comprising:
- a) measuring T2 of the sample of the test subject over time, the T2 being responsive to coagulation in the sample;
- and
- b) comparing T2 of the sample obtained in a) with those of a standard coagulation-time-curve of T2 responsive to normal coagulation to thereby diagnose an abnormal clotting event in the subject.
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Dependencies are inferred from the claim text.