Biomarkers for predicting degree of weight loss

A method for predicting the body mass index that a subject would be expected to attain from a dietary intervention (BMI2), wherein the method comprises:

• a. determining the level of vitamin K-dependent protein C;
• coagulation factor XIII A chain;
• pigment epithelium-derived factor;
• serum amyloid P-component;
• neuroligin-4, X-linked;
• CD226 antigen;
• metalloproteinase inhibitor 3;
• eukaryotic translation initiation factor 4E-binding protein 2;
• leukocyte immunoglobulin-like receptor subfamily B member 2;
• X-ray repair cross-complementing protein 6;
• caspase-2;
• interleukin-34;
• interleukin-17 receptor C;
• protein Z-dependent protease inhibitor;
• serum paraoxonase/arylesterase 1;
• plasminogen;
• complement factor D;
• leptin;
• carbonic anhydrase 6;
• macrophage metalloelastase and angiopoietin-1 in one or more samples obtained from the subject;
• and
• b. predicting BMI2 using formula (1):
• BMI2=c1*BMI1+c2*age−c3*Vitamin K-dependent protein C−c4*Coagulation factor XIII A chain−c5*Pigment epithelium-derived factor−c6*Serum amyloid P-component−c7*Neuroligin-4,X-linked−c8*CD226 antigen−c9*Metalloproteinase inhibitor 3−c10*Eukaryotic translation initiation factor 4E-binding protein 2+c11*Leukocyte immunoglobulin-like receptor subfamily B member 2+c12*X-ray repair cross-complementing protein 6+c13*Caspase-2+c14*Interleukin-34+c15*Interleukin-17 receptor C−c16*Protein Z-dependent protease inhibitor−c17*Serum paraoxonase/arylesterase 1+c18*Plasminogen−c19*Complement factor D+c20*Leptin−c21*Carbonic anhydrase 6+c22*Macrophage metalloelastase−c23*Angiopoietin-1;
• (1)
• wherein BMI1 is the subject's body mass index before the dietary intervention and BMI2 is the subject's predicted body mass index after the dietary intervention;
• and
• wherein c1 to c23 are positive integers.