Detection and treatment of cancer
AssigneeUniversity of Essex Enterprises Limited
InventorMetodi Vladimirov Metodiev
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.
Claims14
A method of diagnosing cancer in a patient, the method comprising detecting the phosphorylation status of at least one of the following residues S1306, S1309, S1348 and S1448 or any combination thereof of a Scribble protein, a fragment or variant thereof, wherein said variant has at least 95% identity to SEQ ID NO:
- 1 and diagnosing cancer in said patient when at least one of the following residues S1306, S1309, S1348 and S1448 or any combination thereof are dephosporylated, wherein detecting the phosphorylation status comprises obtaining a sample from said patient and detecting the phosphorylation status of at least one of the following residues S1306, S1309, S1348 and S1448 or any combination thereof by mass spectrometry, wherein the method comprises measuring the concentration of at least one phosphorylated peptide selected from SEQ ID NO:
- 11 to 15.
A method for detecting the phosphorylation status of a Scribble protein of SEQ ID NO:
- 1 or a fragment or variant thereof, wherein said variant has at least 95% identity to SEQ ID NO:
- 1 the method comprising:
- obtaining a sample from a patient and contacting the sample with at least one antibody that is capable of specifically binding phosphorylated or unphosphorylated residues S1306, S1309, S1348 and S1448 or a combination thereof in the Scribble protein, fragment or variant thereof;
- or
- detecting the phosphorylation status of at least one of the following residues S1306, S1309, S1348 and S1448 or any combination thereof by mass spectrometry.
An antibody capable of selectively binding to at least one phosphorylated or unphosphorylated residue in a Scribble protein with SEQ ID NO:
- 1, or fragment or variant thereof, selected from residues S1306, S1309, S1348 and S1448 or a combination thereof.
Dependencies are inferred from the claim text.