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US 2019/0154683 A1Published application
Hierarchical films having ultra low fouling and high recognition element loading properties
AssigneeUniversity of Washington through its Center for Commercialization
InventorsShaoyi Jiang, Norman David Brault, JR., Harihara S. Sundaram, Chun-Jen Huang, Qiuming Yu, Yuting Li
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Abstract
Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.
Claims23
A surface-anchored polymer assembly, comprising:
- (a) a nonfouling first layer having a first layer density, wherein the first layer comprises a plurality of first polymers, wherein each is attached to a substrate;
- and
- (b) a second layer having a second layer density, wherein the second layer comprises a plurality of second polymers and a plurality of recognition elements attached to the second polymers, wherein the recognition elements are attached throughout the entire second layer, wherein the second layer is attached to the first layer,
- wherein the first layer density is greater than the second layer density.
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A method for making a surface-anchored polymer assembly, comprising:
- (a) forming a first layer having a first layer density on a substrate;
- and
- (b) forming a second layer on the first layer, the second layer having a second density,
- wherein the first layer density is greater than the second layer density.
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Dependencies are inferred from the claim text.