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US 2019/0154679 A1Published application
Apparatuses and methods for cell and tissue assays and agent delivery
AssigneesMassachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Inc.
InventorsPatrick S. Doyle, Augusto M. Tentori, Maxwell Benjamin Nagarajan, Jae Jung Kim, Wen Cai Zhang, Frank J. Slack
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Abstract
Apparatuses and methods for cell and tissue assays and agent delivery are generally described.
Claims73
An apparatus comprising:
- a first microwell array, wherein each microwell in the first microwell array comprises:
- a first post in the microwell;
- wherein the first post comprises a first probe configured to detect a first analyte.
A method of assaying a first analyte in a biological sample, the method comprising:
- exposing a biological sample to a first probe on a first post in a first microwell, wherein the first probe is configured to detect a first analyte.
A method of assaying an analyte in a tissue sample, the method comprising:
- positioning separate probe articles proximate to separate areas of a surface of the tissue sample, wherein at least some of the separate probe articles are configured to detect a first analyte.
A method of delivering an agent, the method comprising:
- wetting a first substrate with a liquid comprising the agent;
- and
- positioning a surface of the first substrate proximate to a surface of a first microwell array such that the contents of each microwell in the first microwell array are physically separated from one another.
Dependencies are inferred from the claim text.