Measurement of fabp for diagnosis
AssigneesRandox Laboratories Limited, Randox Teoranta
InventorsIvan McConnell, Peter Fitzgerald, John Lamont, Ciaran Richardson
Life of this patent
Estimating the term…
Abstract
The present invention relates to a multiplexing system comprising a support substrate having immobilised thereto one or more of the following proteins, fragments thereof or a binding molecule, wherein the binding molecule binds specifically to one of the following proteins: E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP. Another aspect is directed to a method for characterising the pattern of FABP antigens existing within a biological sample to reveal information useful in the diagnosis or disease or injury.
Claims18
A multiplexing system comprising a support substrate having immobilised thereon B-FABP, or a peptide fragment thereof, or a binding molecule, said binding molecule binding specifically to B-FABP,
- additionally comprising one or more of the proteins, IL-FABP, E-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP, or a peptide fragment thereof, or a molecule binding specifically thereof.
A multiplexing system comprising a support substrate having immobilised thereon two or more of the following proteins:
- E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP, or a peptide fragment thereof, or two or more binding molecules, each of said binding molecules binding specifically to a single different one of said proteins.
An immunoassay kit for detecting two or more different FABPs comprising;
- (i) a multiplexing system according to any preceding claim;
- and
- (ii) one or more detection probes capable of binding to said FABPs, said detection probe comprising a detectable label.
A binding molecule that binds B-FABP, with less than 5% cross-reactivity to the other FABP isoforms.
A multiplex system comprising a solid support substrate having immobilised thereon at least one of the following proteins:
- B-FABP, E-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP, or a peptide fragment thereof, or at least one binding molecule, said binding molecule binding specifically to one of said proteins, wherein the solid support has a planar surface and wherein each different protein, binding molecule or peptide fragment is immobilised in a discrete reaction zone on the planar surface.
Dependencies are inferred from the claim text.