Back to results
US 2019/0154662 A1Published application
Method of drug design and optimisation utilizing stereochemical mimicry
AssigneeThe Trustees of the University of Pennsylvania
InventorDavid M. CHENOWETH
Life of this patent
Estimating the term…
Abstract
The invention relates to a method of designing or optimizing a drug candidate by making stereodynamic derivatives as well as novel derivatives of Glyx-13 with improved biological and pharmacological properties.
Claims15
A method for optimizing a compound containing one or more stable chiral atom, comprising:
- generating a plurality of stereodynamic mimic compounds by replacing one or more of the stable chiral atom with a stereodynamic atom capable of mimicking chirality;
- evaluating each of the stereodynamic mimic compounds for relevant biological activities as compared to those of the compound;
- and
- selecting those stereodynamic mimic compounds that show more effective biological activities or different pharmacokinetic or metabolic properties and designating said compounds as improved compounds.
1 more element
A drug screening or discovery method for identifying a drug candidate compound, comprising:
- providing one or more starting compounds, each containing at least one stable chiral atom;
- generating one or more stereodynamic mimic compound for each of the starting compounds;
- evaluating the stereodynamic mimic compounds for a biological, pharmacological or metabolic activity known to be associated with a disease indication;
- and
- selecting as candidate compounds the stereodynamic mimic compounds that showed biological, pharmacological, or metabolic activity associated with the disease indication.
2 more elements
A compound having the structural formula:
A compound having the structural formula:
A compound having the structural formula:
Dependencies are inferred from the claim text.