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US 2019/0154661 A1Published application
Methods of identifying cftr modulators
AssigneeProteostasis Therapeutics, Inc.
InventorsJohn Miller, Lawrence J. Drew, II, Po-Shun Lee
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Abstract
The present disclosure is directed to methods of identifying CFTR modulators using non-mutant or mutant CFTR expressing cells in the presence of a CFTR amplifier compound.
Claims23
A method of identifying a CFTR modulator compound, comprising:
- incubating a set of test compounds in combination with a CFTR amplifier compound with cells expressing a non-mutant or mutant CFTR in incubation media;
- measuring CFTR levels and/or activity;
- and
- identifying one or more compounds from the set of test compounds that modulate CFTR levels or activity, thereby identifying CFTR modulator compounds.
1 more element
Dependencies are inferred from the claim text.