Method of screening, Isolating, and Purifying Rare Cells by Using Dynamic Optical Patterns and Optically-Induced Dielectrophoresis

A method of screening, isolating and purifying rare cells by using dynamic optical patterns and optically-induced dielectrophoresis comprising the steps of:

• (a) obtaining cell groups with rare cells in from a sample, removing cells not to be screened from the cell groups, and then drawing the remaining cells as cell suspension sample;
• (b) activating an introduction device to load the cell suspension sample onto an optically-induced dielectrophoresis chip 14 including a cell isolation zone having a division arrangement wherein at least one optical pattern is configured on the cell isolation zone for screening, isolating and purifying the rare cells, and the at least one optical pattern is configured to migrate, rotate or both;
• and
• (c) activating the screening, isolating and purifying by the optical patterns, the rare cells are attracted into a collection tank on the optically-induced dielectrophoresis chip, thereby activating a liquid drawing device to draw the rare cells out of the collection tank.