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US 2019/0153385 A1Published application
Method of producing progenitor cells from differentiated cells
AssigneeRegenertech Pty Limited
InventorVishal BHASIN
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AssigneeRegenertech Pty Limited
InventorVishal BHASIN
Estimating the term…
The present invention provides a method of producing progenitor cells, such as cells capable of being differentiated into a plurality of different cell types, from differentiated cells. Methods of using progenitor cells in differentiation and/or tissue or organ repair and/or regeneration and/or building are also provides. Methods of using progenitor cells in treatment and prophylaxis of conditions alleviated by administering stem cells or tissue or organ derived from stem cells to a subject or by grafting stem cells or tissue or organ derived from stem cells into a subject or by transplanting stem cells or tissue or organ derived from stem cells into a subject are also provided. Also included are progenitor cells and differentiated cells and/or tissues and/or organs derived therefrom, and kits comprising same.
A method for producing a progenitor cell capable of being differentiated into a plurality of different cell types, said method comprising incubating primary fibroblasts in a medium comprising an amount of one or more modulators of RhoA and/or ROCK pathway for a time and under conditions sufficient to produce a progenitor cell that is capable of being differentiated into a plurality of different cell types, wherein said one or more modulators of RhoA and/or ROCK pathway comprises dexamethasone, and wherein said primary fibroblasts are non-transformed.
Dependencies are inferred from the claim text.