Alcohol-resistant siliconized polycarbonate polyurethanes and medical devices incorporating the same
AssigneePiper Access, LLC
InventorsJay Allen Muse, Nathaniel J. Fredin, Sriram Venkataramani
Life of this patent
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Abstract
An alcohol-resistant siliconized polycarbonate polyurethane can include a soft segment and a hard segment. The soft segment can include a polycarbonate polyol and a polysiloxane, which can be present in an amount less than the polycarbonate polyol. The hard segment can include an isocyanate and a chain extender. Peripherally inserted central catheter (PICC) devices can include one or more components that are at least partially formed from one or more formulations of the siliconized polycarbonate polyurethane catheter. The PICC devices can withstand alcohol locking, and can be power injectable both before and after alcohol locking events.
Claims33
1-55. (canceled)
An alcohol-resistant siliconized polycarbonate polyurethane formed from reactants that comprise:
- a polycarbonate polyol having a structure according to formula (I):
- wherein R is selected from a linear or branched, substituted or unsubstituted C1-C24 alkyl or alkylene group, A is selected from hydrogen (H) or R′OH, and n is an integer from 2 to 30;
- a polysiloxane having a structure according to formula (IV):
- wherein R1 and R2 are independently selected from a linear C1-C6 alkyl group or a hydrogen group, R3 and R5 are independently selected from a C1-C12 alkyl or alkylene group, R4 and R6 are independently selected from a C1-C8 alkyl or alkylene group, and m is an integer from 2 to 30;
- an isocyanate;
- and
- a chain extender,
- the siliconized polycarbonate polyurethane comprising:
- a hard segment;
- a soft segment that comprises the polysiloxane in an amount of from 5 wt % to 15 wt %;
- and
- an isocyanate index of from 1.01 to 1.06.
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70-87. (canceled)
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95-100. (canceled)
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109-248. (canceled)
Dependencies are inferred from the claim text.