Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods

A cryo-stimulation treatment device, the device comprising:

• a needle assembly configured to produce a cold zone for cryoneurolysis of a target nerve, the needle assembly comprising:
• a first shaft constructed of electrically conductive material and including an electrically insulating coating, the first shaft comprising a proximal end, a distal end, and length therebetween, and wherein the proximal end of the first shaft is couplable with an electrical nerve stimulation generator that generates an electric field for electrically stimulating and locating the target nerve;
• a second shaft comprising a proximal end, a distal end, and a shaft lumen extending therebetween;
• and
• a cooling fluid supply lumen extending distally within the shaft lumen to a distal portion of the shaft lumen of the second shaft.

A method of treating a nerve, the method comprising:

• inserting one or more needles of a needle assembly into a tissue of a patient;
• electrically stimulating the nerve with the needle assembly via bipolar electrical stimulation to localize the nerve within the tissue;
• and
• after localizing of the nerve via bipolar electrical stimulation, delivering cryoneurolysis to the nerve with the needle assembly.