Quantitative profiling of progesterone metabolites for the prediction of spontaneous preterm delivery
AssigneeIndiana University Research and Technology Corporation
InventorAvinash Shivaputrappa Patil
Life of this patent
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Abstract
Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based on ratios of steroids in samples obtained from the pregnant female.
Claims27
A method of detecting a ratio of at least two steroids in a pregnant female, the method comprising:
- obtaining a sample from the pregnant female;
- detecting a concentration of a first steroid selected from the group consisting of deoxycorticosterone, corticorterone, 18-hydroxycortiosterone, aldosterone, deoxycortisol, cortisol and combinations thereof in the sample;
- detecting a concentration of at least a second steroid in the sample, wherein the second steroid is different from the first steroid;
- and
- detecting a ratio of the first steroid to the at least second steroid.
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A method of detecting a ratio of deoxycorticosterone (DOC) to 16α-hydroxyprogesterone (16αOHP) in a pregnant female, the method comprising:
- obtaining a sample from the pregnant female;
- detecting a concentration of DOC in the sample;
- detecting a concentration of 16αOHP;
- and
- detecting a ratio of DOC/16αOHP.
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A method for identifying a pregnant female as being susceptible to spontaneous preterm delivery, the method comprising:
- obtaining a sample from the pregnant female;
- determining a concentration of a first steroid selected from the group consisting of deoxycorticosterone, corticorterone, 18-hydroxycortiosterone, aldosterone, deoxycortisol, cortisol and combinations thereof in the sample;
- determining a concentration of at least a second steroid, wherein the second steroid is different from the first steroid;
- calculating a ratio of the first steroid and the at least second steroid;
- and
- identifying the pregnant female as being susceptible to spontaneous preterm delivery when the ratio in the sample is reduced below a threshold value.
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Dependencies are inferred from the claim text.