Methods and compositions for treating heart failure
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsWalter M. Koch, Sarah M. Schumacher-Bass
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Abstract
This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.
Claims19
A composition comprising a βARKnt peptide, a variant thereof, or a fragment thereof;
- or a nucleic acid encoding βARKnt, a variant thereof or a fragment thereof.
A method for treating or preventing heart failure in a subject, the method comprising administering an effective amount of a composition comprising a βARKnt peptide, a variant thereof, or a fragment thereof;
- or a nucleic acid encoding a βARKnt peptide, a variant thereof or a fragment thereof.
A method for altering β-adrenergic receptor (βAR) density in a subject, the method comprising administering an effective amount of a composition comprising a βARKnt peptide, a variant thereof, or a fragment thereof;
- or a nucleic acid encoding a βARKnt peptide, a variant thereof or a fragment thereof.
Dependencies are inferred from the claim text.