Device and method for removing undesirable biological and/or chemical entities from biological fluids

Device for the removal of a biological and/or chemical entity (C) from an extracorporeal blood volume (B) comprising:

• a hollow capture chamber having an inlet for the entry of the extracorporeal blood (B) and an outlet for the outflow of the extracorporeal blood (B) and
• a capture element inside the capture chamber and movable relative to the capture chamber, the capture element having a reactant surface placed in contact with the extracorporeal blood (B) and comprising a plurality of binding agents (A) for the biological and/or chemical entity to be removed (C) such that at the outlet of the capture chamber the biological and/or chemical entity (C) is removed from the extracorporeal blood (B), the biological and/or chemical entity (C) being bonded to the reactant surface,
• wherein the total volume of extracorporeal blood (B) flowing inside the capture chamber is between 1 and 6 TBVs and wherein each TBV consists of up to 5 litres of blood.