Molecular origin of allergy
AssigneeGenclis
InventorsBERNARD BIHAIN, VIRGINIE OGIER, MARIE BRULLIARD, SANDRINE JACQUENET, BENOIT THOUVENOT, OLIVIER ROITEL
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Abstract
The present invention relates to compositions and methods for modulating or detecting allergy in a subject. The invention may be used to reduce allergenicity of compositions, such as food products, or to stimulate immunogenicity of products, such as vaccines. The invention may be used in any mammal such as human.
Claims24
1-24. (canceled)
A method for reducing immunogenicity or allergenicity of a composition, the method comprising treating the composition to remove cationic proteins.
A method for preparing a food product comprising (i) providing a food product preparation, (ii) treating the food product preparation to remove cationic proteins therefrom and (iii) optionally formulating the treated food product with one or more suitable excipients.
A method for preparing a pharmaceutical product comprising (i) providing a pharmaceutical product preparation, (ii) treating the pharmaceutical product preparation to remove cationic proteins therefrom and (iii) optionally formulating the treated pharmaceutical product with one or more suitable excipients.
A food composition comprising a food product and a suitable excipient, wherein the food product contains less than 1% by weight of cationic proteins.
A method for reducing immunogenicity or allergenicity of peanut, the method comprising reducing the transcription infidelity rate in one or more peanut proteins selected from Ara h 1, Ara h 2, Ara h 3, Ara h 5, Ara h 6, Ara h 7, Ara h 8, Ara h 9, Ara h 10 and Ara h 11.
A method for detecting a subject having predisposition to allergy, comprising measuring in a sample from said subject the level of IgE directed against proteins having a sequence resulting from a transcription infidelity, wherein a difference in said level as compared to a control value indicates a subject having predisposition to allergy.
A method of stimulating antibody production in a mammal comprising administering a cationic protein or peptide resulting from transcription infidelity to said mammal to stimulate antibody production.
A vaccine composition comprising an immunogen and a protein or peptide having a sequence resulting from transcription infidelity.
A protein or peptide comprising a sequence selected from SEQ ID NO:
- 1-SEQ ID NO:
- 74 to 109 or SEQ ID:
- 110 to 120, or a fragment thereof containing at least 10 consecutive amino acids thereof or a protein comprising SEQ ID NO:
- 6-10, SEQ ID NO:
- 16 to 51, or SEQ ID NO:
- 121 to 131.
Dependencies are inferred from the claim text.