Protein and Autoantibody Biomarkers for the Diagnosis and Treatment of Lung Cancer
AssigneesMagArray, Inc., The Board of Trustees of the Leland Stanford Junior University
InventorsShan Xiang Wang, Viswam Siva Nair, Heng Yu, Michael J. Beggs, Luis Carbonell
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Abstract
Aspects of the present disclosure include methods of producing a circulating analyte profile of a subject. The methods include contacting a blood sample from a subject with a panel of probes for specific binding to analytes, and detecting the presence or absence of binding of the analytes to probes of the panel of probes. Also provided are sensor devices including a panel of capture probes and useful, e.g., for practicing the methods of the present disclosure.
Claims21
A method of producing a circulating analyte profile of a subject, comprising:
- contacting a blood sample from a subject with a panel of probes for specific binding to two or more analytes selected from the group consisting of:
- tissue inhibitor of metalloproteinase 1 (TIMP1), anti-angiopoietin-like protein 3 antibody (anti-ANGPTL3), epidermal growth factor receptor (EGFR), pro-surfactant protein B (ProSB), anti-14-3-3 protein theta antibody (anti-YWHAQ), and anti-laminin alpha 1 antibody (anti-LAMR1);
- and
- detecting the presence or absence of binding of analytes of the two or more analytes to probes of the panel of probes,
- to produce a circulating analyte profile of the subject.
-19. (canceled)
A sensor device, comprising:
- a panel of capture probes provided as an addressable probe array, wherein the panel comprises probes for specific binding to two or more analytes selected from the group consisting of:
- TIMP1, anti-ANGPTL3, EGFR, ProSB, anti-YWHAQ, and anti-LAMR1.
Dependencies are inferred from the claim text.