Spectrometric Analysis
AssigneeMicromass UK Limited
InventorsKeith George Richardson, Steven Derek Pringle
Life of this patent
Estimating the term…
Abstract
A method of mass or mobility spectrometry comprising obtaining one or more sample spectra for a sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the sample. Before the sample spectra are acquired, a library of background spectra, each background spectrum relating to a certain class of sample material, is constructed. The background spectra in this library are used to subtract the background from a sample spectrum during the pre-processing of this sample spectrum.
Claims20
A method of spectrometric analysis comprising:
- obtaining one or more background reference sample spectra for one or more samples;
- deriving one or more background noise profiles for the one or more background reference sample spectra, wherein the one or more background noise profiles comprise one or more background noise profiles for each class of one or more classes of sample;
- and
- storing the one or more background noise profiles in electronic storage for use when pre-processing and analysing one or more sample spectra obtained from a different sample to the one or more samples.
A method of spectrometric analysis comprising:
- obtaining one or more sample spectra for a sample;
- pre-processing the one or more sample spectra, wherein pre-processing the one or more sample spectra comprises a background subtraction process, wherein the background subtraction process comprises retrieving one or more background noise profiles from electronic storage and subtracting the one or more background noise profiles from the one or more sample spectra to produce one or more background-subtracted sample spectra, wherein the one or more background noise profiles are derived from one or more background reference sample spectra obtained for one or more samples that are different to the sample, and wherein the one or more background noise profiles comprise one or more background noise profiles for each class of one or more classes of sample;
- and
- analysing the one or more background-subtracted sample spectra so as to classify the sample.
A spectrometric analysis system comprising at least one of:
- control circuitry arranged and adapted to:
- obtain one or more background reference sample spectra for one or more samples;
- derive one or more background noise profiles for the one or more background reference sample spectra, wherein the one or more background noise profiles comprise one or more background noise profiles for each class of one or more classes of sample;
- and
- store the one or more background noise profiles in electronic storage for use when pre-processing and analysing one or more sample spectra obtained from a different sample to the one or more samples;
- and
- control circuitry arranged and adapted to:
- obtain one or more sample spectra for a sample;
- pre-process the one or more sample spectra, wherein pre-processing the one or more sample spectra comprises a background subtraction process, wherein the background subtraction process comprises retrieving one or more background noise profiles from electronic storage and subtracting the one or more background noise profiles from the one or more sample spectra to produce one or more background-subtracted sample spectra, wherein the one or more background noise profiles are derived from one or more background reference sample spectra obtained for one or more samples that are different to the sample, and wherein the one or more background noise profiles comprise one or more background noise profiles for each class of one or more classes of sample;
- and
- analyse the one or more background-subtracted sample spectra so as to classify the sample.
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Dependencies are inferred from the claim text.