Methods and tools for detecting, diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject

A method of diagnosing, predicting, prognosticating, or treating a neurobehavioral phenotype in a subject, said method comprising:

• a. obtaining or having obtained a sample of neurobehavioral phenotype mapping data from the subject;
• b. defining a genotype topography of a first brain area for a gene based on gene expression mapping data;
• c. defining a neurophenotype topography of a second brain area for the neurobehavioral phenotype based on neurobehavioral phenotype mapping data;
• d. contacting the genotype topography of the first brain area and the neurophenotype topography of the second brain area to establish an alignment;
• e. detecting whether the neurobehavioral phenotype is present in the sample by contacting the sample with the aligned genotype topography and neurophenotype topography;
• and
• f. diagnosing, predicting, prognosticating, or treating the subject when the neurobehavioral phenotype is detected.

A method for treating a subject with a neurobehavioral phenotype, the method comprising the steps of:

• determining whether the subject has neurobehavioral phenotype mapping data indicative of the neurobehavioral phenotype by:
• obtaining or having obtained a sample of neurobehavioral phenotype mapping data from the subject;
• defining a genotype topography of a first brain area for a gene based on gene expression mapping data;
• defining a neurophenotype topography of a second brain area for the neurobehavioral phenotype based on neurobehavioral phenotype mapping data;
• contacting the genotype topography of the first brain area and the neurophenotype topography of the second brain area to establish an alignment;
• performing or having performed a comparison of the sample with the aligned genotype topography and neurophenotype topography to determine if the subject has the neurobehavioral phenotype;
• and
• if the subject has the neurobehavioral phenotype as determined by comparison of the sample with the aligned genotype topography and neurophenotype topography, then administering a therapeutic agent targeted to one or more genes associated with the aligned genotype topography and neurophenotype topography, or
• if the subject has the neurobehavioral phenotype as determined by comparison of the sample with the aligned genotype topography and neurophenotype topography, then administering a therapeutic agent targeted to one or more neurobehavioral phenotypes associated with the aligned genotype topography and neurophenotype topography.

A method of detecting a neurobehavioral phenotype in subjects of a patient population, said method comprising:

• a. obtaining or having obtained a sample of neurobehavioral phenotype mapping data from each subject in the patient population;
• b. defining a neurophenotype topography of a second brain area for the neurobehavioral phenotype based on neurobehavioral phenotype mapping data;
• c. contacting the genotype topography of the first brain area and the neurophenotype topography of the second brain area to establish an alignment;
• d. detecting whether the neurobehavioral phenotype is present in the sample by contacting the sample with the aligned genotype topography and neurophenotype topography.