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US 2019/0101550 A1Published application
Ceramides for evaluating risk of cardiovascular disease
AssigneesWashington University, Trustees of Boston University
InventorsJean E. SCHAFFER, Daniel S. ORY, Linda PETERSON, Vasan S. RAMACHANDRAN, Venessa XANTHAKIS
Life of this patent
Estimating the term…
Abstract
The present disclosure provides the use of two very long chain ceramides for determining the risk of cardiovascular disease.
Claims24
A method to determine if a subject is at risk of cardiovascular disease (CVD), the method comprising:
- measuring an amount of ceramide 24:0, and optionally ceramide 22:0, in a biological sample obtained from the subject;
- comparing the amount of ceramide 24:0, and optionally ceramide 22:0, in the biological sample to a reference value;
- and
- classifying the subject as at risk for CVD if the amount of ceramide 24:0, and optionally ceramide 22:0, is less than the reference value.
1 more element
A method to prevent cardiovascular disease (CVD) in a subject, the method comprising:
- measuring an amount of ceramide 24:0, and optionally ceramide 22:0, in a biological sample obtained from the subject;
- comparing the amount of ceramide 24:0, and optionally ceramide 22:0, in the biological sample to a reference value;
- classifying the subject as at risk for CVD if the amount of ceramide 24:0, and optionally ceramide 22:0, is less than the reference value;
- and
- treating the subject to prevent future CVD events when the subject is at risk for CVD.
2 more elements
(canceled)
A method for monitoring cardiovascular disease (CVD) in a subject, the method comprising:
- measuring an amount of ceramide 24:0, and optionally ceramide 22:0, in a biological sample obtained from the subject;
- and
- then at a later time, measuring the amount of ceramide 24:0, and optionally ceramide 22:0, in a biological sample obtained from the subject,
- wherein a change in ceramide 24:0, and optionally ceramide 22:0, indicates a change in risk of the subject over time.
1 more element
18-19. (canceled)
(canceled)
24-27. (canceled)
Dependencies are inferred from the claim text.