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US 2019/0101544 A1Published application
Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
AssigneeVenn Biosciences Corporation
InventorsLieza Marie Araullo Danan-Leon, Aldo Mario Eduardo Silva Carrascoso, Carolyn Ruth Bertozzi, Carlito Bangeles Lebrilla
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Abstract
Provided herein are methods for identifying new biomarkers for various diseases using proteomics, peptidomics, metabolics, proteoglycomics, glvcomics, mass spectrometry and machine learning. The present disclosure also provides glycopeptides as biomarkers for various diseases such as cancer and autoimmune diseases.
Claims20
A method for identifying glycosylated peptide fragments as potential biomarkers, comprising:
- fragmenting glycosylated proteins in each of a plurality of biological samples isolated from subjects, with one or more proteases, to produce glycosylated peptide fragments;
- quantitating the glycosylated peptide fragments with liquid chromatography and mass spectrometry (LC-MS) to provide quantitation results;
- analyzing the quantitation results along with classification of the subjects with a machine learning method to select glycosylated peptide fragments useful for predicting the classification;
- and
- determining the identity of glycosylated peptide fragments.
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