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US 2019/0101539 A1Published application
Metabolomic based biomarkers for colon cancer detection
AssigneeUniversity of Southern California
InventorsDavid CONTI, Fredrick SCHUMACHER, Stan LOUIE, Isaac ASANTE
Life of this patent
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Abstract
A method of identifying subjects with colorectal cancer (CRC) is provided. The method includes obtaining a sample from a subject, determining a level of one or more folate one carbon metabolism (FOCM) metabolites in the sample of the subject, and comparing the level of the FOCM metabolites in the sample of the subject to a level in a non CRC control.
Claims21
A method of identifying subjects with colorectal cancer (CRC) comprising:
- obtaining a sample from a subject;
- determining a level of one or more folate one carbon metabolism (FOCM) metabolites in the sample of the subject;
- and
- comparing the level of the FOCM metabolites in the sample of the subject to a level in a non CRC control.
1 more element
A method of quantifying folate one carbon metabolism (FOCM) metabolites in a sample from a subject comprising:
- adding a stabilization agent to the sample of the subject;
- determining a level of one or more folate one carbon metabolism (FOCM) metabolites in the sample of the subject by conducting a liquid chromatograph mass spectrometry (LC-MS) assay;
- and
- adjusting the determined level of the FOCM metabolites to a level at a time of collection of the sample.
1 more element
Dependencies are inferred from the claim text.