Animal model for studying zcchc6 in bone disease and development
AssigneeNortheast Ohio Medical University
InventorTariq M. HAQQI
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Abstract
A transgenic knockout non-human animal is described whose genome includes a heterozygous disruption of the expression of at least one endogenous gene encoding zinc-finger, CCHC domain-containing protein 6 (ZCCHC6). The transgenic animal model can be used to study bone disease or development by determining differences in bone characteristics, protein expression, or cytokine expression in the animal model in comparison to a corresponding wild-type non-human animal.
Claims12
A transgenic knockout non-human animal whose genome comprises a heterozygous disruption of the expression of at least one endogenous gene encoding zinc-finger, CCHC domain-containing protein 6 (ZCCHC6).
A method of studying the role of zinc-finger, CCHC domain-containing protein 6 (ZCCHC6) in bone disease or development, comprising the steps of obtaining an animal model comprising a non-human animal having a heterozygous disruption of the expression of at least one endogenous gene encoding ZCCHC6, and determining differences in bone or cartilage characteristics, protein expression, or cytokine expression in the animal model in comparison to a corresponding wild-type non-human animal.
Dependencies are inferred from the claim text.