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US 2019/0100802 A1Published application
Marker for predicting pressure ulcer development and use thereof
AssigneeThe University of Tokyo
InventorsHiromi SANADA, Gojiro NAKAGAMI, Takeo MINEMATSU
Life of this patent
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Abstract
A marker for predicting pressure ulcer development, selected from the group consisting of interleukin (IL)-1α, vascular endothelial growth factor (VEGF)-C, plasminogen activator inhibitor (PAI)-1, and heat-shock protein (HSP) 90α.
Claims9
(canceled)
A kit for predicting pressure ulcer development, comprising:
- a primer set for amplifying cDNA of IL-1α, VEGF-C, PAI-1, or HSP90α;
- a probe specifically hybridize with mRNA of IL-1α, VEGF-C, PAI-1, or HSP90α;
- and
- a specific binding substance to a IL-1α protein, a VEGF-C protein, a PAI-1 protein, or an HSP90α protein.
1 more element
A method for predicting and preventing pressure ulcer development, comprising:
- measuring an expression amount of IL-1α, VEGF-C, PAI-1, or HSP90α in a specimen derived from a subject area of a patient,
- predicting pressure ulcer development in the subject area, in a case where the expression amount of IL-1α, VEGF-C, or PAI-1 is increased compared to that of a control, and
- performing appropriate intervention to prevent pressure ulcer development when pressure ulcer development is predicted.
(canceled)
A method for predicting and preventing pressure ulcer development, comprising:
- measuring an existing amount of a PAI-1 protein in a blood specimen derived from a patient,
- predicting pressure ulcer development in the patient in a case where the existing amount of the PAI-1 protein is increased compared to that of a control, and
- performing appropriate intervention to prevent pressure ulcer development when pressure ulcer development is predicted.
A method for producing a pressure ulcer non-human animal model, comprising:
- pinching the skin of a non-human animal and loading a pressure of 133.322 kPa for 6 hours.
Dependencies are inferred from the claim text.