Transgenic rabbit with common light chain
AssigneeHoffmann-La Roche Inc.
InventorJosef Platzer
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Abstract
Herein is reported a transgenic vector comprising a humanized light chain locus, wherein said humanized light chain locus comprises (a) a V gene segment derived from human light chain V segment IGKV1-39-01, (b) 3′ proximal to said light chain gene segment a promoter, and (c) 5′ proximal to said light chain gene segment at least a fragment of the human IGKJ4 J-element.
Claims13
A method of generating a bispecific antibody comprising:
- use of a common antibody light chain comprising a variable domain that has the amino acid sequence of SEQ ID NO:
- 01 or is a variant thereof.
A bispecific full-length antibody comprising two heavy chains and two common light chains each comprising a variable domain that has the amino acid sequence of SEQ ID NO:
- 01 or is a variant thereof.
A transgenic vector comprising a humanized light chain locus, wherein said humanized light chain locus comprises
- (a) as V gene segment the human light chain V segment IGKV1-39-01,
- (b) 3′ proximal to said light chain gene segment a promoter, and
- (c) 5′ proximal to said light chain gene segment the human IGKJ4 J-element or a functional fragment thereof.
Dependencies are inferred from the claim text.