US 2019/0100598 A1 · ANTI-KIT ANTIBODIES AND USES THEREOF

Abstract

Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.

Claims64

Dependent claims

An antibody, which immunospecifically binds to a D4/D5 region of human KIT (SEQ ID NO:

15), comprising:
(i) a variable light (“VL”) chain region comprising a VL CDR1, VL CDR2, and VL CDR3 having the amino acid sequences of SEQ ID NO:
20, SEQ ID NO:
21, and SEQ ID NO:
22, respectively;
and
(ii) a variable heavy (“VH”) chain region comprising a VH CDR1, VH CDR2, and VH CDR3 having the amino acid sequences of SEQ ID NO:
23, SEQ ID NO:
24, and SEQ ID NO:
25, respectively.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/214,980Filed 10 Dec 2018

Priority

26 Jan 2011

Published

4 Apr 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification29 codes

C07K 16/2896
Against receptors, cell surface antigens or cell surface determinants: against molecules with a "CD"-designation, not provided for elsewhere
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Family

Application61/436,483Us provisional application · filed 26 Jan 2011

Application61/507,430Us provisional application · filed 13 Jul 2011

Application61/537,482Us provisional application · filed 21 Sep 2011

Application13/981,852Division · filed 11 Nov 2013

Application15/361,936Division · filed 28 Nov 2016

Application16/214,980Division

US 10,189,907 B2Related patent

US 10,793,639 B2Related patent

US 2014/0056905 A1Published application

US 2017/0073422 A1Published application

US 9,540,443 B2Related patent

US 2019/0100598 A1This patent

From the US filing history. Foreign family members aren’t listed.

Anti-kit antibodies and uses thereof

Life of this patent

Anti-kit antibodies and uses thereof

Life of this patent

Abstract

Claims64