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AssigneeBoard of Regents, The University of Texas System
InventorsYong-Jun LIU, Kui Shin VOO, Laura BOVER, Naoya TSURUSHITA, J. Yun TSO, Shankar KUMAR
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Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
An isolated antibody which binds to OX40 comprising:
An isolated antibody which binds to OX40 comprising:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 7 or 19, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 8 or 20, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 9 or 21, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 1 or 13, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 2 or 14, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds OX40 comprising the amino acid sequence of SEQ ID NO. 3 or 15, or an antibody comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
An isolated antibody that binds to an epitope on OX40 recognized by an antibody having a heavy chain variable region comprising the amino acid sequences of SEQ ID NO. 5 or 17 and a light chain variable region comprising the amino acid sequences of SEQ ID No. 11 or 23, or an antibody having amino acid sequences with at least 90 percent homology thereto.
An isolated antibody which binds OX40 comprising, a light chain variable region having CDRs comprising the amino acid sequences of SEQ ID NO:
An isolated antibody which binds OX40 comprising, a heavy chain variable region having CDRs comprising the amino acid sequences of SEQ ID NO:
Dependencies are inferred from the claim text.