Multivalent and multispecific gitr-binding fusion proteins
AssigneeInhibrx, Inc.
InventorsJohn C. TIMMER, Kyle S. JONES, Amir RAZAI, Abrahim HUSSAIN, Katelyn M. WILLIS, Quinn DEVERAUX, Brendan P. ECKELMAN
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Abstract
This disclosure generally provides molecules that specifically engage glucocorticoid-induced TNFR-related protein (GITR), a member of the TNF receptor superfamily (TNFRSF). More specifically, the disclosure relates to multivalent and/or multispecific molecules that bind at least GITR.
Claims43
A polypeptide that binds glucocorticoid-induced TNFR-related protein (GITR), comprising two or more GITR-binding domain (GITR-BD) that specifically binds GITR.
A polypeptide that binds glucocorticoid-induced TNFR-related protein (GITR), comprising at least one GITR-binding domain (GITR-BD) comprising a complementarity determining region 1 (CDR1) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 106, 109, 112, 117, 120, 125, 131, 138, 143, 148, and 149;
- a complementarity determining region 2 (CDR2) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 107, 110, 113, 115, 118, 121, 123, 128, 130, 132, 134, 136, 137, 139, 141, 144, and 147;
- and a complementarity determining region 3 (CDR3) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 108, 111, 114, 116, 119, 122, 124, 126, 127, 129, 133, 135, 140, 142, 145, 146, and 150.
A polypeptide that binds at least glucocorticoid-induced TNFR-related protein (GITR), comprising at least one GITR-binding domain (GITR-BD) that specifically binds GITR and one or more additional binding domain.
Dependencies are inferred from the claim text.