Method for inhibiting bone resorption

A method for increasing bone mineral density in a subject, the method comprising administering to the subject a sclerostin binding agent in an amount from about 1 mg/kg to about 10 mg/kg,

• wherein the amount is effective to (a) reduce serum level of CTX by at least 20% compared to pre-treatment or normal levels, by 3 weeks after treatment begins, and (b) increase serum level of a bone formation marker selected from the group consisting of serum level of bone-specific alkaline phosphatase (BSAP), serum level of amino-terminal extension of peptide of procollagen type 1 (PINP), and serum level of osteocalcin (OstCa), by at least 20%, compared to pre-treatment or normal levels, by 3 weeks after treatment begins,
• and wherein bone mineral density is increased.

A method for treating a bone-related disorder in a subject, the method comprising (a) administering to the subject a sclerostin binding agent in an amount from about 1 mg/kg to about 10 mg/kg for a first period of time, wherein the amount is effective to increase bone mineral density at the hip, spine, wrist, finger, shin bone and/or heel by at least about 3%, and

• (b) administering to the subject a sclerostin binding agent in an amount of from about 1 mg/kg to about 10 mg/kg for a second period of time effective to maintain bone mineral density.

A method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, the method comprising administering to the human a sclerostin binding agent in a therapeutically effective amount from about 1 mg/kg to about 10 mg/kg.

A method of treating a bone-related disorder in (a) a human in which treatment with a parathyroid hormone or analog thereof is contraindicated or (b) a human in which treatment with bisphosphonate is contraindicated, the method comprising administering to the human a therapeutically effective amount of a sclerostin binding agent from about 1 mg/kg to about 10 mg/kg.