Anti-pacap antibody
AssigneeEli Lilly and Company
InventorsChetankumar Natvarlal Patel, Michael Parvin Johnson, Catherine Brautigam Beidler
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Abstract
Antibodies to human pituitary adenylate cyclase-activating peptide, compositions comprising such antibodies, and methods of using such antibodies for the treatment of pain including headache and/or migraine.
Claims18
An antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain variable region (HCVR) and a light chain variable region (LCVR), wherein the HCVR comprises complementarity determining regions (CDRs) HCDR1, HCDR2, and HCDR3 and the LCVR comprises CDRs LCDR1, LCDR2, and LCDR3, wherein the amino acid sequence of HCDR1 is SEQ ID NO.3, the amino acid sequence of HCDR2 is SEQ ID NO.4, the amino acid sequence of HCDR3 is SEQ ID NO.5, the amino acid sequence of LCDR1 is SEQ ID NO.6, the amino acid sequence of LCDR2 is SEQ ID NO.7, and the amino acid sequence of LCDR3 is SEQ ID NO.8.
An antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain (HC) and a light chain (LC), wherein the amino acid sequence of the HC is SEQ ID NO.1 and the amino acid sequence of the LC is SEQ ID NO.2.
Dependencies are inferred from the claim text.