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US 2019/0100576 A1Published application
Signal biomarkers
AssigneeUpstream Medical Technologies Limited
InventorsChristopher Joseph Pemberton, Arthur Mark Richards
Life of this patent
Estimating the term…
Abstract
Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefore.
Claims18
-18. (canceled)
An antibody, or antigen-binding fragment thereof, which specifically binds a fragment peptide of erythropoietin signal peptide (EPOsp) selected from EPOsp(1-9) peptide having an amino acid sequence consisting of SEQ ID NO:2 or EPOsp(18-27) peptide having an amino acid sequence consisting of SEQ ID NO:3,
- wherein the antibody, or antigen-binding fragment thereof is immobilized on a solid matrix or is labeled.
A composition comprising:
- a first anti-erythropoietin signal peptide (EPOsp) antibody, or antigen-binding fragment thereof, immobilized on a solid matrix;
- an EPOsp or fragment thereof bound to the first anti-EPOsp antibody, or antigen-binding fragment thereof, and
- a second anti-EPOsp antibody, or antigen-binding fragment thereof, bound to the EPONsp or fragment thereof, wherein the second anti-EPOsp antibody, or antigen-binding fragment thereof, binds to a site on EPOsp or fragment thereof that is different from the site bound by the first anti-EPOsp antibody, or antigen-binding fragment thereof,
- wherein
- either the first or the second anti-EPOsp antibody, or antigen-binding fragment thereof, is the anti-EPOsp antibody, or antigen-binding fragment thereof, which specifically binds a peptide of EPOsp selected from EPOsp(1-9) peptide having an amino acid sequence consisting of SEQ ID NO:2 or EPOsp(18-27) peptide having an amino acid sequence consisting of SEQ ID NO:3.
2 more elements
A kit comprising:
- a first anti-erythropoietin signal peptide (EPOsp) antibody, or antigen-binding fragment thereof, immobilized on a solid matrix;
- and
- a second anti-EPOsp antibody, or antigen-binding fragment thereof, wherein the second anti-EPOsp antibody, or antigen-binding fragment thereof, binds to a site on EPOsp or fragment thereof that is different from the site bound by the first anti-EPOsp antibody,
- wherein
- either the first or the second anti-EPOsp antibody, or fragment thereof, is the anti-EPOsp antibody, or antigen-binding fragment thereof, which specifically binds a peptide of EPOsp selected from EPOsp(1-9) peptide having an amino acid sequence consisting of SEQ ID NO:2 or EPOsp(18-27) peptide having an amino acid sequence consisting of SEQ ID NO:3.
2 more elements
Dependencies are inferred from the claim text.