Antibodies specific for enteroviruses that infect humans
AssigneeMAB Explorations Sdn Bhd
InventorMary Jane Cardosa
Life of this patent
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Abstract
This invention provides antibodies or fragments thereof that are capable of specifically binding to at least one conformational epitope of Human Enterovirus 71 (EV71), wherein the antibody individually comprises at least one variable light chain and at least one variable heavy chain. There is also provided a method of producing an antibody capable of specifically binding to at least one conformational epitope of Human Enterovirus 71 (EV71).
Claims11
An isolated antibody or epitope-binding fragment thereof that specifically binds to at least one conformational (non-linear) epitope of enterovirus 71 (EV71), wherein the antibody comprises at least one variable light chain and at least one variable heavy chain, wherein the variable light chain comprises an amino acid sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID NO:
- 3, and wherein the variable heavy chain comprises an amino acid sequence selected from an amino acid sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID NO:
- 4 and an amino acid sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID NO:
- 5, wherein the antibody or fragment thereof is neutralizing.
Dependencies are inferred from the claim text.