Back to results
US 2019/0100571 A1Published application
Chimeric antigen receptor
AssigneeUCL Business PLC
InventorsMartin Pulé, Kwee Yong, Lydia Lee, Ben Draper
Life of this patent
Estimating the term…
Abstract
The present invention provides a chimeric antigen receptor (CAR) comprising; (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
Claims15
A chimeric antigen receptor (CAR) which comprises:
- (i) a truncated proliferation-inducing ligand (APRIL) that
- (a) binds B cell maturation antigen (BCMA) and
- (b) binds transmembrane activator and calcium modulator and cylophilin ligand interactor (TACI);
- (ii) a spacer domain;
- and
- (ii) a transmembrane domain;
- and
- (iii) an intracellular T cell signaling domain.
5 more elements
14-18. (canceled)
Dependencies are inferred from the claim text.