Proteins with diagnostic and therapeutic uses
AssigneeThe University Court of the University of Edinburgh
InventorsPaul Barlow, Andrew Herbert, Elisavet Makou
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Abstract
The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH. Methods and medical devices for using utilising the same are also described.
Claims52
A recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH.
A composite comprising a recombinant protein bound to complement factor H (CFH), the composite inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH, wherein CFH is held in a conformation, or conformations, that is/are more active than the conformation or conformations adopted by CFH alone.
A nucleic acid encoding a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH.
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A method of purifying or separating CFH from a sample, the method comprising:
- providing a protein immobilized on a surface, the protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3d by bound CFH compared to unbound CFH;
- providing a sample;
- passing the sample over the surface;
- and
- recovering CFH bound to the surface;
- and/or
- recovering the sample that is devoid or depleted of CFH.
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A pharmaceutical preparation comprising a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH, or a nucleic acid encoding the same.
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A method of treatment or prevention of a disease in a subject by administration to a subject of an effective amount of a pharmaceutical composition comprising a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH, or a nucleic acid encoding said recombinant protein.
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Dependencies are inferred from the claim text.