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AssigneeShanghai Institute of Materia Medica, Chinese Academy of Sciences
InventorsHong LIU, Jiang WANG, Jian LI, Jia LI, Jingya LI, Hualiang JIANG, Xiaomin LUO, Kaixian CHEN
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The invention describes a polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid maleate and a preparation method therefor. The polymorph is a crystal having high stability and low hygroscopicity, and the crystal form is selected from crystal form A, crystal form B and crystal form C. Furthermore, the crystal form has a strong in-vivo hypoglycemic activity and can be used for the preparation of a novel drug for the treatment or prevention of diabetes mellitus type H and/or complications of diabetes mellitus type H.
A crystal form of a compound of formula I, wherein the crystal form is a crystal having high stability and low hygroscopicity, and the crystal form is selected from the group consisting of crystal form A crystal form B and crystal form C
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