Methods of treating cancer
AssigneeEpizyme, Inc.
InventorsSarah K. Knutson, Natalie Warholic, Heike Keilhack
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Claims24
A method for treating or alleviating a symptom of a SWI/SNF-associated cancer in a subject comprising administering to a subject in need thereof a therapeutically effective amount of an EZH2 inhibitor, wherein the subject has a cancer selected from the group consisting of brain and central nervous system cancer, head and neck cancer, kidney cancer, ovarian cancer, pancreatic cancer, leukemia, lung cancer, lymphoma, myeloma, sarcoma, breast cancer, and prostate cancer.
9-18. (canceled)
A method of inducing neuronal differentiation, cell cycle inhibition, gene expression or tumor suppression comprising contacting a cell with an EZH2 inhibitor.
A method of inhibiting hedgehog signaling or gene expression comprising contacting a cell with an EZH2 inhibitor.
(canceled)
25-26. (canceled)
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Dependencies are inferred from the claim text.