Novel derivatives and their use as selective inhibitors of caspase-2

A compound of formula (I):

• wherein:
• Z1 is a (C1-C6)alkyl group;
• P5 is selected from the following amino acid residues
• P1 and P4, identical or different, are selected from the following amino acid residues
• in which Z2 and Z3, identical or different, are selected from a hydrogen atom and a (C1-C6)alkyl group;
• P3 is selected from the following amino acids residues
• R1 is selected from
• and
• R2 is selected from
• in which
• m is 0, 1 or 2;
• p is 1, 2, 3 or 4;
• Z4 is a halogen atom;
• q is 0 or 1;
• Z5 is selected from a (C1-C6)alkyl and a phenyl group, said phenyl group being substituted or not by an amino group;
• Z6, Z7 and Z10, identical or different, are selected from a hydrogen atom, a (C1-C4)alkyl, a tetrahydroquinolynyl and a —(CH2)i-aryl group with i being 0, 1 or 2, said aryl group being substituted or not by one, two, three, or four halogen atom(s) or one (C1-C4) alkyl group;
• and
• Z8 and Z9, identical or different, are selected from a halogen atom and a (C1-C6)alkyl group;
• or one of its salts;
• said compound of formula (I) being in all the possible racemic, enantiomeric and diastereoisomeric isomer forms.