Pyrrole Derivatives

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Ar1 is a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms selected from the group consisting of N, O and S, wherein the 5- to 10-membered ring system is optionally substituted with 1-3 substituents independently selected from alkyl, halogen, —OH, —CN, nitro, alkoxy, —CF3, —O—CF3, —S(CH3), —O-alkyl, —S-alkyl, —S(O)-alkyl, —S(O2)-alkyl, —S(O2)-aryl, —CH2-aryl, heteroaryl, alkanoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)cycloalkyl, —C(O)heterocycloalkyl, wherein the substituents optionally combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring, or
• a 5- to 10-membered mono- or bicyclic aryl ring, wherein the 5- to 10-membered aryl ring is optionally substituted with 1-3 substituents independently selected from alkyl, -halogen, —OH, —CN, nitro, alkoxy, —CF3, —OCF3, —S(CH3), —O-alkyl, —S-alkyl, —S(O)-alkyl, —S(O2)-alkyl, —S(O2)-aryl, —CH2-aryl, heteroaryl, alkanoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)cycloalkyl, —C(O)-heterocycloalkyl, wherein the substituents optionally combine to form a 5-7 membered fused and optionally substituted carbacyclic or heterocyclic ring;
• Ar2 is a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms independently selected from the group consisting of N, O and S, wherein the 5- to 10-membered ring system is optionally substituted with 1-3 substituents independently selected from alkyl, halogen, —OH, —CN, nitro, alkoxy, —CF3, —OCF3, —S(CH3), —OCH3, —S-alkyl, —S(O)-alkyl, —S(O2)-alkyl, —S(O2)-aryl, —CH2-aryl, heteroaryl, alkanoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, or substituted lower alkyl wherein the substituents optionally combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring, or
• a 5- to 10-membered mono- or bicyclic aryl ring, wherein the 5- to 10-membered ring system is optionally substituted with 1-3 substituents independently selected from alkyl, —F, —Cl, —Br, —OH, —CN, nitro, alkoxy, —CF3, —OCF3, —S(CH3), —OCH3, —S-alkyl, —S(O)-alkyl, —S(O2)-alkyl, —S(O2)-aryl, —CH2-aryl, heteroaryl, alkanoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)cycloalkyl, —C(O)-heterocycloalkyl, or substituted lower alkyl wherein the substituents optionally combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring;
• P is a heteroaryl ring selected from
• and
• R1, R2 and R3 are independently selected from —H, halogen, —OH, —CN, nitro, alkyl, alkoxy, —CF3, —OCF3, —CH2-aryl, phenyl, heteroaryl, alkanoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)O-alkyl, —C(O)O-aryl, wherein the substituents optionally combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring.